Skip to content
Medical Health Aged Care, National News Current Affairs

New discovery for treatment of primary liver cancer

Monash University 2 mins read
Drug discovery

A preclinical study led by Monash University has discovered a drug combination with the potential to treat one of the most fatal and globally widespread cancers, a type of primary liver cancer called hepatocellular carcinoma (HCC).

The team of researchers from the Monash Institute of Pharmaceutical Sciences (MIPS) found the drug combination reverses the symptoms of nonalcoholic steatohepatitis (NASH) and, subsequently, markedly reduces the onset of NASH-driven HCC, without affecting the liver in mice.

The study, published in Science Advances, used a mouse model that mimics human NASH-driven HCC to implement a combination treatment of an endoplasmic reticulum (ER) stress inhibitor called ‘BGP-15’ with the inflammation blocker, ‘Olamkicept’. 

Both of these drugs are already proven to be safe in humans and have progressed to Phase 2 and 3 human clinical trials for other metabolic and/or inflammatory diseases. 

The study’s lead author, Professor Mark Febbraio from MIPS, said this is an exciting discovery for a particularly widespread and devastating disease with a low survival rate.

“HCC is increasing at an alarming rate largely due to increased obesity and type 2 diabetes which may lead to NASH, a well known HCC risk factor,” said Professor Febbraio. 

The rise in HCC coincides with patients presenting with obesity and symptoms associated with the metabolic syndrome, especially metabolic dysfunction-associated fatty liver disease (MAFLD). Globally, a staggering 25 per cent of the population are estimated to be living with MAFLD, with around 15 per cent of those exhibiting signs of NASH.

“Despite the high prevalence of NASH and the alarming rise in NASH-driven HCC, there are currently no FDA approved treatments that halt disease progression.

“Given that ER stress and inflammation are hallmarks of NASH-driven HCC, and that BGP-15 and Olamkicept have both already proven to be safe, we tested whether these drugs – as monotherapy, or in combination – would prevent NASH and/or NASH driven HCC in mice.

“Consistent with our hypothesis, the study shows that while monotherapy with either of the two drugs modestly slowed progression, when combined they have shown to be a realistic therapeutic strategy for treating human NASH and progression to HCC, diseases that are rapidly growing with a clinical unmet need.”

Professor Febbraio said that given the significance of the discovery, combined with the urgent need for new safe and effective treatments for NASH and NASH-driven HCC, the team ultimately hope their findings will progress toward clinical trials. 

“We have to stress that this study was performed in mice, not humans. However, as both drugs have been shown to be safe in several human clinical trials, the logical next step is testing the BGP-15/Olamkicept combination in clinical trials for patients with NASH and or HCC.”

Contact details:

Kate Carthew - Media and Communications Manager
T: +61 (0) 438 674 814


More from this category

  • Medical Health Aged Care
  • 26/07/2024
  • 00:06
The Australian Primary Health Care Nurses Association (APNA)

New funding for the next generation of Australia’s primary health care nurses

The Australian Primary Health Care Nurses Association (APNA) says the Albanese Government’s $4.2 million investment in the APNA National Nursing Clinical Placements Program (NNCPP) will help to grow the next generation of primary health care nurses and combat the workforce shortage. The funding is aimed at placing 6,000 nursing students over the next three years and in South Australia alone, 50 students have already been placed in primary health care settings, a number that will grow to 500 placements in the next three years. Speaking at the APNA Essential Health Summit at the Adelaide Convention Centre today (Friday 26 July),…

  • Medical Health Aged Care
  • 25/07/2024
  • 20:11

The Texas Heart Institute Implants BiVACORĀ® Total Artificial Heart

First-in-human novel valveless artificial heart implanted in a patient with end-stage heart failure as a bridge to heart transplant HOUSTON–BUSINESS WIRE– The Texas Heart…

  • Contains:
  • Medical Health Aged Care
  • 25/07/2024
  • 19:00
The Australian Primary Health Care Nurses Association (APNA)

APNA Media Alert for Friday 26 July, 2024

Over 1000 health care professionals from all across the country will attend today’s Australian Primary Health Care Nurses Association (APNA) Essential Health Summit and Primary Heatlh Care Congress (Friday 26th July 2024) where funding to create the next generation of Australian nurses will be announced by Assistant Minister for Health and Aged Care the Hon Ged Kearney. What: APNA Essential Health Summit and Primary Health Care Congress. Who: Assistant Minister for Health and Aged Care Ged Kearney; Member for Boothby Louise Miller-Frost MP; APNA President Karen Booth; APNA CEO Ken Griffin; Australian College of Nurse Practitioners (ACNP) President Melanie Dunstan;…

Media Outreach made fast, easy, simple.

Feature your press release on Medianet's News Hub every time you distribute with Medianet. Pay per release or save with a subscription.