Skip to content
Medical Health Aged Care, Science

Australian scientists develop a new method for the detection of Alzheimer’s

Monash University 2 mins read
Sourced from Unsplash

A team of Australian scientists, led by Monash University and The University of Sydney, has developed a new method for the detection of neurodegenerative diseases, such as Alzheimer’s, by “lighting up” clusters of misfolded proteins in the brain.

In Alzheimer’s disease, protein clusters known as 'amyloids' accumulate to abnormally high levels in the brain. Distinct amyloids have been associated with the onset of various neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease. 

As such, the swift detection and recognition of different amyloids in the brain is crucial for early diagnosis of amyloid-related neurodegenerative diseases. 

In this study, completed by a team led by Dr Amandeep Kaur, ARC DECRA Fellow at the Monash Institute of Pharmaceutical Sciences (MIPS) and Professor Elizabeth New and Professor Margaret Sunde from The University of Sydney, the team reports the development of an array of fluorescent sensors with the ability to correctly differentiate between different amyloids associated with neurodegenerative diseases and, therefore, monitor disease progression.

The team also tested the sensors’ performance on samples taken from the brains of mouse models of Alzheimer’s disease and observed that the fluorescence patterns differed between early (at age 6 months) and later (at age 12 months) stages of the disease.

Dr Kaur said although there are several methods for detection of amyloids, they are far from perfect and there is a lot of work to be done to develop methods for earlier and accurate diagnosis of Alzheimer’s disease and other types of dementia.

Alzheimer’s is an irreversible neurodegenerative disorder; however, there are many advantages to early detection including enhanced medical attention, management of symptoms and, hopefully, future treatments that will be able to target the disease in its earliest stages, before irreversible brain damage or cognitive decline has occurred,” said Dr Kaur.

Dr Kaur, Professor New and Professor Sunde collaborated to develop a solution to this pressing need, bringing together their expertise in chemistry, fluorescent sensors and amyloid biology. 

“Our team focused on developing a versatile fluorescent sensor array for amyloids to monitor Alzheimer’s and other disease progression and to distinguish these disease-associated amyloids from similar, naturally occurring amyloids that play functional roles,” said Dr Kaur.

“It is our hope this method, using an array of sensors that can light up amyloids, could be used as a tool for researchers to help distinguish between many different types of amyloids and could inform new strategies for early and decisive diagnosis of amyloid-related diseases.”

This study was published in the journal ACS Sensors. Click here to read the full study. 

https://doi.org/10.1021/acssensors.3c01334 

ENDS

 

 


Contact details:

Kate Carthew

kate.carthew@monash.edu 

+61 438 674 814

Media

More from this category

  • Environment, Medical Health Aged Care
  • 12/04/2024
  • 14:56
Climate Media Centre

Government heat map ‘wake up call’ to stop burning fossil fuels

Friday 12 April 2024 Advocacy groups have welcomed the release of the Federal Government’s announcement of a heat mapping tool to assist affected communities deal with the worst of extreme heat, but have called on government to do more to address the root cause, climate change caused by the continued use of fossil fuels. Emma Bacon, Executive Director of Sweltering Cities “Heatwaves are Australia’s deadliest environmental disaster, so we welcome the Government’s acknowledgement of the severe impacts being felt by communities across the country. Clearly, some of the communities most impacted in areas like Western Sydney are facing climate, health,…

  • Biotechnology, Medical Health Aged Care
  • 12/04/2024
  • 13:40
UNSW

UNSW and Mid North Coast Local Health District to boost research and students in rural communities

The strategic partnership will place UNSW students at local hospitals and streamline research collaboration opportunities. UNSW Sydney has signed an historic three-year Memorandum of…

  • Contains:
  • Medical Health Aged Care, Sport Recreation
  • 12/04/2024
  • 08:46
Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney

Industry backing for Wipeout Dementia raises $2.5 million for research

No amount of wild weather could stop Olympic Bronze Medalist Owen Wright and 1999 World Surfing Champion Mark Occhilupo from joining Sydney’s property industry…

  • Contains:

Media Outreach made fast, easy, simple.

Feature your press release on Medianet's News Hub every time you distribute with Medianet. Pay per release or save with a subscription.