Skip to content
Science

Merck Provides Update on Phase III TrilynX Study in Locally Advanced Head and Neck Cancer

Merck 3 mins read

Not intended for UK-, US- or Canada-based media


DARMSTADT, Germany--BUSINESS WIRE--

Merck, a leading science and technology company, today announced the discontinuation of the Phase III randomized TrilynX study evaluating xevinapant plus chemoradiotherapy (CRT) in patients with unresected locally advanced squamous cell carcinoma of the head and neck (LA SCCHN). The decision follows a pre-planned interim analysis performed by the study’s Independent Data Monitoring Committee, which found that the trial would be unlikely to meet its primary objective of prolonging event-free survival. Top-line safety data were overall compatible with the chemo-radio sensitizing properties of xevinapant. The company will conduct an in-depth review of the data and will share the results in a peer-reviewed forum.

LA SCCHN has proven to be a difficult-to-treat form of cancer. CRT has remained the standard of care for decades, despite multiple studies designed to improve outcomes with new treatment approaches, including multiple immunotherapy trials.

“We sincerely thank the patients, caregivers and clinical investigators who participated in this trial,” said Danny Bar-Zohar, Global Head of Research & Development and Chief Medical Officer for the Healthcare business sector of Merck. “While we are disappointed by these results, we remain steadfast in our commitment to develop transformative medicines within our oncology portfolio for areas of high unmet need.”

Given the totality of the data, the company decided to also stop the Phase III clinical trial X-Ray Vision (xevinapant plus radiotherapy, compared to placebo plus radiotherapy) in patients who underwent resection of locally advanced head and neck cancer.

Merck is working to develop and deliver new treatment options that exploit the vulnerabilities of tumor cells. The company is exploring modalities including antibody-drug conjugates (ADCs) and DNA damage response (DDR) inhibitors, across multiple tumor types, including many that have proven difficult to treat where there are significant unmet needs for patients. The company’s support for the head and neck cancer community remains steadfast with Erbitux®, approved in combination with radiotherapy for the initial treatment of locally advanced SCCHN, and which continues to be studied in more than 200 active clinical trials, including at least 15 Phase III studies.

About Xevinapant

Xevinapant (formerly known as Debio 1143) is an investigational potent oral small-molecule IAP (inhibitor of apoptosis protein) inhibitor. In March 2021, Merck gained exclusive rights from Debiopharm International SA to develop and commercialize xevinapant worldwide. Xevinapant is not approved for any use anywhere in the world.

Advancing the Future of Cancer Care

At Merck we strive every day to improve the futures of people living with cancer. Our research explores the full potential of promising mechanisms in cancer research, focused on synergistic approaches designed to hit cancer at its core. We are determined to maximize the impact of our standard-of-care treatments and to continue pioneering novel medicines. Our vision is to create a world where more cancer patients will become cancer survivors. Learn more at www.merckgrouponcology.com.

About Merck

Merck, a leading science and technology company, operates across life science, healthcare and electronics. Around 63,000 employees work to make a positive difference to millions of people’s lives every day by creating more joyful and sustainable ways to live. From providing products and services that accelerate drug development and manufacturing as well as discovering unique ways to treat the most challenging diseases to enabling the intelligence of devices – the company is everywhere. In 2023, Merck generated sales of € 21 billion in 65 countries.

Scientific exploration and responsible entrepreneurship have been key to Merck’s technological and scientific advances. This is how Merck has thrived since its founding in 1668. The founding family remains the majority owner of the publicly listed company. Merck holds the global rights to the Merck name and brand. The only exceptions are the United States and Canada, where the business sectors of Merck operate as MilliporeSigma in life science, EMD Serono in healthcare, and EMD Electronics in electronics.

All Merck press releases are distributed by e-mail at the same time they become available on the Merck website. Please go to www.merckgroup.com/subscribe to register online, change your selection or discontinue this service.


Contact details:

Media Relations
gangolf.schrimpf@merckgroup.com
Phone: +49 151 1454-9591

Investor Relations
investor.relations@merckgroup.com
Phone: +49 6151 72-3321

Media

More from this category

  • Defence, Science
  • 16/07/2024
  • 14:14
Charles Darwin University

CDU strengthens defence ties with Alliance

Charles Darwin University (CDU) will bring its strategic location and unique research capabilities to the table of an important organisation dedicated to advancing Australia’s…

  • Contains:
  • Science
  • 16/07/2024
  • 08:01
PsiQuantum

PsiQuantum Partners with Queensland Universities, Bolstering the Future of Quantum Computing in Australia

The consortium of Queensland universities includes The University of Queensland, Griffith University, Queensland University of Technology, University of Southern Queensland and the University of the Sunshine Coast. BRISBANE, Queensland. PsiQuantum will partner with five leading universities in Queensland, after signing a memorandum of understanding, to help support the growing demand for skills in the quantum computing economy and to explore research projects in adjacent fields. This collaboration will provide a framework for academic institutions in Australia to offer opportunities for academic, postgraduate, and undergraduate placements that will attract and retain leading Australian and global talent. Within this partnership,PsiQuantum will work…

  • Science
  • 15/07/2024
  • 15:11
Botanic Gardens of Sydney

MEDIA RELEASE: NEW STUDY – AI REVOLUTIONISNG SCIENTISTS’ UNDERSTANDING OF ICONIC AUSTRALIAN NATIVE

Scientists at Botanic Gardens of Sydney have harnessed new developments in machine learning to look at Australian eucalypt species, unveiling their transformation over millions…

  • Contains:

Media Outreach made fast, easy, simple.

Feature your press release on Medianet's News Hub every time you distribute with Medianet. Pay per release or save with a subscription.