Skip to content
Medical Health Aged Care, Science

Discovering a new way blood vessel growth is controlled

La Trobe University 2 mins read

La Trobe University and Phillipps-University of Marburg (Germany) scientists have discovered how a peptide called Apelin regulates blood vessel growth, opening new avenues of research for cancer treatment, organ regeneration, and tissue engineering.

The study, published in Science Advances, revealed that when Apelin is produced by self-renewing stem cells in the nervous system called “neuro progenitor cells”, it regulated the signals to the body which coordinate how blood vessels grow.

La Trobe University researcher Dr Kazuhide Shaun Okuda, whose zebrafish research and imaging expertise played key roles in this study, said this discovery could open the way to develop new therapeutics which regulate blood vessel growth.

“Understanding how blood vessels develop could lead to new treatments to stop excessive blood vessel growth in diseases like cancer. It could also lead to treatments in settings where you need to promote blood vessel growth, such as for organ regeneration and in tissue engineering,” Dr Okuda said.

This is the first time neuro progenitor cell-derived Apelin, one of several “growth factor” peptides secreted by many different types of cells, has been shown to be directly responsible for blood vessel development.

They observed that Apelin stimulates and regulated new blood vessel growth.

The research team observed the blood vessel development in living zebrafish, which are transparent as embryos and while young.  

Understanding how Apelin controls blood vessel development opens an important research pathway for cancer treatments, as the peptide could potentially be targeted to control the excessive blood vessel growth caused by the disease.

The discovery is also important for the burgeoning research areas of organ regeneration and tissue engineering, both of which need blood vessels to promote growth and deliver nutrients.

“There’s research that suggests that it can help with cardiac regeneration for example,” Dr Okuda said. 

This research collaboration was led by Professor Christian Helker at the Phillip-University of Marburg and the Centre for Mind, Brain and Behaviour, University of Marburg and Justus Liebig University Giessen.

Link to paper:

DOI: 10.1126/sciadv.adk1174 

Contact details:

Elaine Cooney
0487 448 734

More from this category

  • Community, Medical Health Aged Care
  • 22/07/2024
  • 17:24
Odyssey Lifestyle Care Communities

Dancing and dining; seniors celebrate four fabulous years

Odyssey Lifestyle Care Communities recently celebrated a significant milestone in style, marking its fourth birthday with an evening full of fun, fantastic food and…

  • Contains:
  • Biotechnology, Medical Health Aged Care
  • 22/07/2024
  • 12:56

Research into psychedelic medicines to treat anxiety wins ANS Illumina Neurogenomics Award 2024

Genomic technologies to discover biological markers, within the blood, that could predict patient response to psychedelic medicines such as psilocybin. MELBOURNE, AUSTRALIA, 22 July 2024 - Illumina Inc. (NASDAQ: ILMN), a global leader in DNA sequencing and array-based technologies, today announced the winner of the annual Australasian Neuroscience Society (ANS) Illumina Neurogenomics Research Award as Dr Andrew Gibbons from the Department of Psychiatry, School of Clinical Sciences at Monash Health. “Psilocybin, a chemical produced by hallucinogenic mushrooms, is a psychedelic medicine that has shown to meaningfully reduce symptoms of generalized anxiety during psychotherapy for patients. However, not all patients respond.…

  • Contains:
  • Industrial Relations, Medical Health Aged Care
  • 22/07/2024
  • 11:12
Australian Nursing and Midwifery Federation (Victorian Branch)

Bolton Clarke nurses and carers to hold stop-work rally – Mon 22 July, 1pm-2pm

WHATANMF Bolton Clarke members two-hour stop work and community rally for fair pay and conditionsACTU Secretary Sally McManus and VTHC Secretary Luke Hilakari will address the rally WHENMonday, 22 July 2024, 1pm-3pm. (Speakers will start 1.05pm sharp) WHEREoutside Bolton Clarke’s Victorian headquarters, 347 Burwood Highway, Forest Hill Bolton Clarke nurses, personal care workers and midwives will stop work for two hours on Monday 22 July to rally for better pay and conditions. For the past 18 months, the Australian Nursing and Midwifery Federation (Victorian Branch) has been negotiating wages and conditions on behalf of about 1700 members working across Bolton…

  • Contains:

Media Outreach made fast, easy, simple.

Feature your press release on Medianet's News Hub every time you distribute with Medianet. Pay per release or save with a subscription.