Despite facing some of the highest rates of chronic disease later in life, a new study has found remote First Nations Australians are born with a natural health advantage: a rich and diverse gut microbiome.
The natural health advantage was uncovered through a study conducted by WEHI in collaboration with The Peter Doherty Institute for Infection and Immunity (Doherty Institute) and Elders in the Northern Territory, that compared the gut bacteria of Indigenous and non-Indigenous infants.
The findings provide a crucial blueprint for future studies to better understand how to prevent westernisation from eroding this strong marker of early-life health, and why First Nations Australians are over-represented in chronic diseases despite this healthy start.
At a glance
- Landmark study reveals Indigenous infants in remote Australia are born with more diverse gut bacteria – a key marker of early-life health – than non-Indigenous infants living in urban Australia.
- Indigenous infants were also found to have bacteria that have completely disappeared from non-Indigenous populations, highlighting how Westernisation can impact health outcomes.
- The findings provide a critical foundation for further studies looking at ways to prevent
Westernisation from eroding the natural gut health of Indigenous Australians.
Chronic diseases, like heart disease and diabetes, disproportionately affect Aboriginal and Torres Strait Islander peoples and are a leading cause of death in these communities.
These chronic disorders have been linked to Westernisation, particularly processed diets high in sugar, fats and additives.
In non-Indigenous communities, Western diets have been shown to reduce the diversity and composition of the gut microbiome – the trillions of micro-organisms that live in our digestive system which are essential for our health.
But in remote Indigenous communities, it remains unknown whether such changes are present in early life, are transmitted across generations, or are acquired throughout adulthood.
Study lead, Professor Leonard Harrison, said his team’s findings address this knowledge gap by showing Indigenous infants aren’t born with a gut microbiome associated with chronic disease.
“Indigenous infants start life as some of the healthiest Australians, but statistics show this drastically changes over time,” Prof Harrison said.
“The richer and more diverse a person’s gut microbiome is, the less chance they have of developing chronic diseases.
“Our team wants to learn how we can preserve the remarkable gut microbiome First Nations Australians are born with and protect them against developing chronic diseases later in life.
“Preserving this natural health advantage that we now know they are born with would be a major step in closing the health gap.”
The vanishing species
The Doherty Institute and WEHI researchers worked closely with Elders and Indigenous health workers in remote Northern Territory to co-design the child gut health study that collected samples from 50 Indigenous infants.
These samples were then compared with data from non-Indigenous infants of the same age and sex, collected through the ENDIA study – a world-first longitudinal study tracking nearly 1500 children across Australia to understand what causes type 1 diabetes.
The Indigenous infants displayed markedly greater diversity and abundance of beneficial bacteria, viruses and fungi – some of which have now vanished from the gut microbiomes of non-Indigenous Australians.
The University of Melbourne’s Professor Beverley-Ann Biggs, Head of Global and Indigenous Health Group at the Doherty Institute, who spearheaded the field study, said the absence of these bacteria in non-Indigenous people shows how Western lifestyles have reshaped the gut microbiome over generations.
“Despite the mothers having access to Western foods, Indigenous infants retain a highly diverse gut microbiome, rich in fibre-degrading bacteria and balanced in ways that support strong early immune development,” Prof Biggs said.
“Our work provides an important window into how lifestyle, culture and environment shape biology from the very beginning of life.
“By reconnecting microbiome science with Indigenous perspectives and lived experiences, we have an opportunity to design nutrition, maternal-child health and chronic disease prevention programs that respect cultural strengths while addressing modern health challenges.”
Researchers hope to track the gut microbiomes of these study participants at varying time points in the future, to monitor how their gut microbiomes change and why.
The study, “Indigenous infants in remote Australia retain an ancestral gut microbiome despite
encroaching Westernization”, is published in Nature Communications.
(DOI: 10.1038/s41467-025-65758-0).
About us:
About WEHI (Walter and Eliza Hall Institute of Medical Research)
WEHI is where brilliant minds collaborate and innovate to make life-changing scientific discoveries that help people live healthier for longer. Our medical researchers have been serving the community for more than 100 years, making transformative discoveries in cancer, infection and immunity, and lifelong health. WEHI brings together diverse and creative people with different experience and expertise to solve some of the world’s most complex health problems. With partners across science, health, government, industry, and philanthropy, we are committed to long-term discovery, collaboration, and translation. At WEHI, we are brighter together.
Find out more at www.wehi.edu.au
Contact details:
M: +61 475 751 811
E: [email protected]